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警惕!新冠病毒再添新变异株

根据美国疾病控制与预防中心(CDC),5月10日发布的数据,一种被命名为KP.2的新冠变异株目前已经取代JN.1成为美国的主要流行株。    Sidney Powell, one of 18 co-defendants in former President Donald Trump's election interference case in Georgia, has taken a plea deal in which she has agreed to testify in the case.She is pleading guilty to six misdemeanor charges, according to the agreement read in court Thursday. She will get 12 months of probation for each count, as well as a $6,000 fine.As part of the agreement, Powell must "testify truthfully about any co-defendants" involved in the case and "provide all documents to the district attorney's office" relevant to their case against the other co-defendants, according to Fulton County Judge Scott McAfee.Steve Sadow, Trump's lead counsel in the Georgia case, responded to Powell's plea deal by telling ABC News in a statement, "Assuming truthful testimony in the Fulton County case, it will be favorable to my overall defense strategy."Powell's plea comes a day before she was scheduled to go on trial along with co-defendant Kenneth Chesebro.Chesebro, according to sources, last month rejected a similar plea deal with the state, ABC News was first to report yesterday.Regarding Powell's plea deal, former Georgia prosecutor Chris Timmons told ABC News, "From the D.A.'s Office's perspective, it can help them in a number of ways. It focuses the trial to acts that are relevant to Mr. Chesebro. It also means the State's witnesses are facing one cross examination instead of two."Prosecutors accused Powell, a former Trump campaign attorney, of helping tamper with voting machines in Coffee County as part of efforts to overturn the 2020 presidential election.She is not to "have any communication" with any of the co-defendants in the case or members of the media, per the terms of her agreement.She will also have to write an apology letter to the people of the state of Georgia, "which you have already satisfied," McAfee said during Thursday's court proceeding.Powell, Chesebro, Trump, and 16 others pleaded not guilty in August to all charges in a sweeping racketeering indictment for alleged efforts to overturn the results of the 2020 election in the state of Georgia.Powell is the second defendant in the case to strike a plea agreement after Georgia bail bondsman Scott Hall last month took a plea deal in which he pleaded guilty to tampering with voting machine equipment and received probation in exchange for agreeing to testify at the trial of other co-defendants.Chesebro, an attorney, is facing seven counts after prosecutors said he drafted a strategy to use so-called "alternate electors" to prevent Joe Biden from receiving 270 electoral votes in the 2020 election, according to the indictment.Jury selection in his case is scheduled to get underway Friday.。

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新冠KP.2变异株于今年3月在美国下水道被监测到,当时仅占新冠感染病例的1%,此后迅速蔓延。

C | 截至5月11日的两周内,KP.2变异株占到美国新冠病毒感染的28%,4月中旬这一比例仅为6%。


已在多国迅速蔓延
世卫:还会衍生新变异株

据记者梳理,全球范围来看,KP.2变异株在全球多国开始蔓延。当地时间5月9日,据Global News报道,KP.2迅速在加拿大占据主导地位,截至4月28日,全国数据显示,KP.2占加拿大所有COVID-19病例的26.6%,超过其他JN.1亚变种。

今年5月初,世界卫生组织(WHO)将KP.2亚变种列为监测中变异株。世卫组织新冠技术负责人Maria Van Kerkhove此前表示,KP.2是奥密克戎变异株JN.1的后代谱系,而JN.1是目前全球主要流行株,KP.2刺突蛋白有额外的突变。

世界卫生组织表示,随着JN.1不断变异,还会衍生出新的变异株,将继续密切监测病毒的演变。
国家疾控局通报我国最新情况:
本土病例中已监测到25条KP.2序列

5月14日,国家疾控局发布健康提示,介绍新冠病毒KP.2变异株相关情况。目前,JN.1变异株仍为全球优势流行株。我国现阶段的主要流行株构成比排在前三位的为JN.1、JN.1.16和JN.1.4,3月11日首次从广东本土病例中监测到KP.2变异株。截至5月12日,在我国本土病例中共监测到25条KP.2序列。每周报告的本土序列中KP.2占比在0.05%~0.30%之间,处于极低水平。

5月13日,南方医科大学公共卫生学院生物安全研究中心主任赵卫告诉记者,考虑感染过的人群已经有一定的抗体水平和免疫屏障,所以即使有新的变异株,目前变异株感染后的症状,仍主要是轻型和无症状感染者。此外,出现新的变异株,提示我们新冠病毒并未消失,并且病毒仍在变异,从临床上来看,现在的变异株虽增加了传播优势,但是感染者的临床症状和以前的毒株没有区别,致病性目前看也没有明显增加,重症率应不会增加。

图据中疾控《2023年4月全国新型冠状病毒感染疫情情况》。

“KP.2变异株是JN.1的衍生株,在最外面的刺突蛋白上有两个氨基酸的点突变,导致传染性增强,这可能是其迅速成为主流变异株的主要原因,在国际上看,现在已经超过JN.1成为一些国家的主要流行毒株,正是因此,也有很多人担心引发新一轮的感染高峰,但是需要明确的是,只要致病力没有明显增加,就暂时可以不用过多担心。”赵卫解释。

“从临床观察看,这一变异株株仍然和其它Omicron突变株一样,传染性极强,但致病性较弱。现阶段,病毒出现新的变异株对大家的正常生活不会有明显影响,但对于老年人和免疫低下人群仍有可能出现重症病例,所以提醒这些高风险人群应继续关注有关部门发布的信息,病毒流行期间做好个人防护。

D | ”赵卫提醒,病毒未来变异仍有可能出现更有传播优势的毒株,甚至不排除出现致病力强的毒株,要持续监测病毒变化、研发更安全有效的疫苗。


一、什么是KP.2变异株?

KP.2是新冠病毒奥密克戎JN.1变异株的第三代亚分支,也是JN.1变异株中具有较强传播优势的一个亚分支,于2024年1月2日在印度采集的样本中首次监测到。2月以来,由于KP.2在全球流行毒株中的占比增长较快,世界卫生组织于5月3日将KP.2列入“需要监测的变异株”。目前尚未检索到KP.2的致病力和免疫逃逸能力较当前流行的JN.1变异株发生明显改变的报道。

二、国际上KP.2变异株的流行情况如何?

目前,JN.1变异株仍为全球优势流行株。今年以来,KP.2亚分支在全球流行毒株中的占比逐渐增加,从1月上旬的0.16%增长至5月上旬的14%左右。

E | 近期,部分国家KP.2亚分支流行程度相对较高,占比为10%~30%。


三、我国开始流行KP.2变异株了吗?

我国现阶段的主要流行株构成比排在前三位的为JN.1、JN.1.16和JN.1.4,3月11日首次从广东本土病例中监测到KP.2变异株。

F | 截至5月12日,在我国本土病例中共监测到25条KP.2序列。每周报告的本土序列中KP.2占比在0.05%~0.30%之间,处于极低水平。


四、KP.2变异株传播得更快吗?

KP.2新增变异位点中,有2个位于S蛋白,提示具有更强的传播力。但KP.2仍为JN.1变异株的亚分支,现有研究认为,其传播优势较JN.1变异株其他亚分支不会有大幅提升。专家研判认为,考虑到当前KP.2亚分支感染病例在我国本土病例中的占比极低,以及此前我国JN.1引起的疫情目前已经降低到较低水平,KP.2亚分支短期内成为我国优势流行株的可能性低,引发新一次感染高峰的可能性低。

五、如何预防KP.2变异株感染?

与预防其他奥密克戎变异株感染一样,建议公众继续保持良好个人卫生习惯,科学佩戴口罩,坚持规律作息,保证健康饮食,提高机体免疫力。

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本文综合自:国家疾病预防控制局监测预警司、健康时报等

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Published on:06:26:23


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